CXCR4 antagonists inhibit radiation-induced PF.

<p>Mice underwent hemithoracic irradiation (20-Gy) and treated with CXCR4 antagonists or their corresponding vehicle controls (n=10/group). <i>A</i>, Lungs were evaluated histologically after trichrome staining (dark bars) or by CT scan (light bars) at 20-weeks post-irradiation. Histologic evaluation was scored (0-12) in each lung as described in the Methods section. CT scan evaluation was scored as the percent volume of lung with density>-200 HU. In all assessments, the vehicle controls values were normalized to 100% with drug-treated values expressed relative to corresponding controls to evaluate the efficacy of the CXCR4 antagonists in attenuating radiation-induced PF. Error bar represents SEM. * indicates statistically significant difference (p<0.05) compared with vehicle controls. <i>B</i>, Representative micrographs of trichrome staining are shown in 4X and 40X magnification.