Variant search space.

<p>Real and hypothetical variants are graphed by effect size (y-axis) and population frequency (x-axis). Known Alzheimer’s disease SNPs are blue circles and hypothetical SNPs are red circles. The large box on the right outlined with dots, is the GWAS search space and the smaller box on the left, outlined with dashes, is the next-generation sequencing search space. Known Alzheimer’s disease SNPs are those found in Table 1 as well as APP and TREM2, which are both labeled on the graph.