Trastuzumab impairs systolic function in mice.

<p>Mice received either trastuzumab (10mg/kg/day) (N = 10) or vehicle injections (N = 6). VEF (a),FS (b), heart rate (d), LVPW thickness (c), left ventricular systolic (f) and diastolic (e) diameter were evaluated at base line (day 0), and days 3 and 7 post injection. Data are presented as percentage of control animals (mean ± SEM). *P < 0.05 vs. the vehicle treated animals.