RAGEΔICD affects RAGE-ligand signaling.

<p><b>A.</b> C6 glioma cells expressing RAGE or RAGEΔICD were stimulated with 5 ug/ml S100B for 5 minutes. Cell lysate was subjected to Western blot for antibodies against phospho-ERK1/2, p38 and SAPK/JNK. GAPDH was detected in total cell lysate by Western blot using monoclonal anti-GAPDH for normalization. <b>B–D</b>. Quantification of triplicate repeats normalized to GAPDH was performed for pERK (B), p38 (C), and pJNK, where *, p<0.05 and **, p = 0.005.