Resveratrol inhibits the Wnt/β-catenin signaling through regulating MALAT1.in CRC HCT116 cells.

<p>(A): Resveratrol inhibited the proliferation of HCT116 cells with an IC50 of 100 µM. (B): HCT 116 cells showed lower MALAT1 expression than LoVo cells. **<i>p</i><0.01, compared with LoVo cells. (C): Overexpression of MALAT1 in HCT116 cells. (D): Overexpression of MALAT1 promoted the in vitro growth of HCT116 cells. (E): Overexpression of MALAT1 attenuated the suppressive effect of resveratrol on migration and invasion in HCT116 cells. HCT116 cells expressing MALAT1-overexpressed, empty vector were treated with or without 50 µM resveratrol for 48 hours and cellular migration and invasion ability were measured. (F): Whole or cell extracts of different cellular compartments from HCT116 cells expressing MALAT1-overexpressed, empty vector treated with or without 50 µM resveratrol for 48 hours were probed for β-catenin, c-Myc, MMP-7 and the protein levels were quantified. *<i>p</i><0.05 or **<i>p</i><0.01, compared with HCT116 cells treated with 100 µM resveratrol.