Cyclooxygenase inhibition prevents perivascular adipose-dependent potentiation of contractions to serotonin in monogenic obesity.

<p>Aortic rings with perivascular adipose (PVAT) from monogenic obese GPER⁰ mice or lean WT (control) mice were pretreated with the cyclooxygenase inhibitor meclofenamate (Meclo, 1 µmol/L) prior to stimulation with increasing concentrations of serotonin. Inset: Area under the curve (AUC) of concentration-response curves is expressed as arbitrary units (AU). , control, untreated (<i>n</i> = 6); , control, meclofenamate (<i>n</i> = 7); , GPER⁰, untreated (<i>n</i> = 7); GPER⁰, meclofenamate (<i>n</i> = 6). *<i>P</i><0.001 <i>vs.</i> untreated vascular rings; †<i>p</i><0.05 <i>vs.</i> control.