A flowchart of meta-analysis loop.

<p>Distance matrices are calculated from <i>N</i> related PDB entries in form of Cartesian coordinates. The lower triangles of the distance matrices are assembled into columns of matrix <b>A</b>. The first a few significant left singular vectors in <b>U</b> resulting from SVD are reconstructed to form decomposed lower triangles. The corresponding singular values and right singular vectors are presented in a multidimensional conformational space. Any given location in this space leads to a recomposed lower triangle by a linear combination of the significant lower triangles. Finally, a hypothetical structure is determined by distance geometry using all constraints in the recomposed lower triangle.