OGR1 mRNA expression in lung is increased by OVA sensitization/challenge.
- Haruka Aoki (482808)
- Chihiro Mogi (482809)
- Takeshi Hisada (482810)
- Takashi Nakakura (482811)
- Yosuke Kamide (328919)
- Isao Ichimonji (482812)
- Hideaki Tomura (482813)
- Masayuki Tobo (482814)
- Koichi Sato (207269)
- Hiroaki Tsurumaki (482815)
- Kunio Dobashi (482816)
- Tetsuya Mori (208605)
- Akihiro Harada (482817)
- Masanobu Yamada (287163)
- Masatomo Mori (65179)
- Tamotsu Ishizuka (482818)
- Fumikazu Okajima (482819)
Publication date
November 2013
DOIAbstract
<p>WT and <i>OGR1<sup>-/-</sup></i> mice were sensitized by OVA/alum and challenged by OVA. To nonsensitized mice, PBS was injected and inhaled. Lung mRNA expression of OGR1 and other proton-sensing GPCRs was measured 48 h after last antigen challenge. The results are mean <u>+</u> SEM of 9 determinations from three separate experiments. *The effect of OVA-priming (WT-PBS vs. WT-OVA) was significant. <sup>§</sup>The expression of OGR1 mRNA was undetectable.</p
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