TVA+ cells in TTA mammary glands can be induced to form tumors by RCAS-<i>PyMT</i>.

<p>(A) Kaplan-Meier tumor-free survival curve of TTA mice infected with RCAS-<i>PyMT</i>. Age: 12∼16 weeks. N = 14. (B) RCAS-<i>PyMT</i>-induced tumors are adenocarcinoma. H&E staining of a representative RCAS-<i>PyMT</i>-induced tumor from TTA mice is shown. (C) Immunofluorescent staining for K8 and K5 in RCAS-<i>PyMT</i>-induced tumors. (D) Immunohistochemistry staining for K6, ERα, and TVA in RCAS-<i>PyMT</i>-induced tumors. Scale bar = 20 µm.