Atrasentan does not prevent proteinuria in adriamycin nephropathy.

<p>(A) In this prevention protocol, treatment with atrasentan (5 mg/kg i.p., open triangles) was started one day prior to administration of a single dose of adriamycin (ADR, 10 mg/kg i.v., closed triangle) or saline vehicle (Ctrl). Mice were sacrificed 7 days after adriamycin injection, at which time urine, blood, and tissues were collected. (B) Urinary albumin excretion was determined for each mouse and normalized for urinary creatinine excretion (n=11 for Ctrl group, n=12 for ADR group, and n=12 for ADR / ATR group). *<i>P</i> < 0.05 compared to the Ctrl group. (C) Serum creatinine is shown for all mice in a similar fashion. There was no significant difference between groups at this early time point.