Genome scans in sporadic Alzheimer’s disease (AD) have revealed possible susceptibility loci on chromosome 12. Recently, two studies were published investigating the +1071 and +1073 polymorphisms in the lectin-like oxidised low density lipoprotein receptor (OLR1) gene with AD, a gene that lies within the area of chromosome 12 linkage. OLR1 is a good candidate gene, due to its function in lipid metabolism pathways, other components of which have been previously implicated as risk factors for AD. We undertook an association study in our UK cohort of 356 AD patients and 358 matched controls, using the same polymorphisms and performing the same sub-group and haplotype analysis as previously described. We found no association with AD in our case...
Alzheimer disease (AD) is the most common cause of dementia. Accumulation of senile plaques and neur...
Expression of ornithine transcarbamylase (OTC) is strongly induced in the brain of individuals suffe...
Several studies have investigated the role of the neuronal sortilin-related receptor (SORL1) gene in...
The þ1073 C/T polymorphism of the oxidized low-density lipoprotein receptor-1 (OLR1) gene has been ...
Although possession of the e 4 allele of the apolipoprotein E gene appears to be an important biolog...
Genome scans in sporadic Alzheimer's disease (AD) have revealed a possible susceptibility locus on c...
A total sample of 169 AD patients, and 264 age- and sex-matched unrelated caregivers from Apulia, so...
The epsilon 4 allele of the apolipoprotein E gene (ApoE) is associated with an increased risk for sp...
The oxidized LDL receptor 1 gene (OLR1) rs1050283 single nucleotide polymorphism (SNP) has been prev...
In recent years, there was an increasing interest on candidate genes may play an important role in t...
It is presently unclear whether polymorphic variations in the oxidized low-density lipoprotein recep...
The low density lipoprotein receptor-related protein 1 (LRP1 gene) is a candidate gene for Alzheimer...
Several years ago reports linked an area on chromosome 12 with Alzheimer's disease.1 More recently, ...
Alzheimer's disease (AD) is characterised by the extensive deposition of amyloid beta (Aβ) within th...
A novel polymorphism (-491 A/T) within the regulatory region on the apolipoprotein E gene has recent...
Alzheimer disease (AD) is the most common cause of dementia. Accumulation of senile plaques and neur...
Expression of ornithine transcarbamylase (OTC) is strongly induced in the brain of individuals suffe...
Several studies have investigated the role of the neuronal sortilin-related receptor (SORL1) gene in...
The þ1073 C/T polymorphism of the oxidized low-density lipoprotein receptor-1 (OLR1) gene has been ...
Although possession of the e 4 allele of the apolipoprotein E gene appears to be an important biolog...
Genome scans in sporadic Alzheimer's disease (AD) have revealed a possible susceptibility locus on c...
A total sample of 169 AD patients, and 264 age- and sex-matched unrelated caregivers from Apulia, so...
The epsilon 4 allele of the apolipoprotein E gene (ApoE) is associated with an increased risk for sp...
The oxidized LDL receptor 1 gene (OLR1) rs1050283 single nucleotide polymorphism (SNP) has been prev...
In recent years, there was an increasing interest on candidate genes may play an important role in t...
It is presently unclear whether polymorphic variations in the oxidized low-density lipoprotein recep...
The low density lipoprotein receptor-related protein 1 (LRP1 gene) is a candidate gene for Alzheimer...
Several years ago reports linked an area on chromosome 12 with Alzheimer's disease.1 More recently, ...
Alzheimer's disease (AD) is characterised by the extensive deposition of amyloid beta (Aβ) within th...
A novel polymorphism (-491 A/T) within the regulatory region on the apolipoprotein E gene has recent...
Alzheimer disease (AD) is the most common cause of dementia. Accumulation of senile plaques and neur...
Expression of ornithine transcarbamylase (OTC) is strongly induced in the brain of individuals suffe...
Several studies have investigated the role of the neuronal sortilin-related receptor (SORL1) gene in...