Measurement of the GLA protein level in serum/plasma using the MUSTag beads assay.

<p><b>A.</b> The GLA concentrations in the serum samples from male patients with classic Fabry disease (Male Fabry), male subjects with p.E66Q (E66Q), and control subjects (Control). <b>B.</b> The GLA concentrations in the plasma samples collected from male patients with classic Fabry disease (Male Fabry), female patients with Fabry disease (Female Fabry), male subjects with p.E66Q (E66Q), and controls (Control). Statistically significant differences are marked with asterisks: *p<0.05; **p<0.01; ***p<0.001. All experimental data are shown as the mean (bold horizontal bars) ± S.D. (Error bars). <b>C.</b> The relationship between the enzymatic activity and protein level of GLA in the serum. <b>D.</b> The relationship between the enzymatic activity and protein level of GLA in the plasma. In each figure, closed circles (•), open circles (○), closed triangles (▴), and closed boxes (▪) show the data for samples from the Male Fabry, Female Fabry, E66Q, and Control groups, respectively.