Muscle weakness caused by TGF-β1 over-expression in skeletal muscles after doxycycline removal.

<p>(A) Expression of the <i>TGF-β1</i> mRNA in various organs. <i>TGF-β1</i> transcripts were detected in the two muscles, quadriceps and diaphragm, examined (lanes 1 and 2), but not in the brain, heart, lung, liver, kidney or ovary (lanes 3–7, respectively). Lane 8 is a no RT control. (B) GSM showed that muscle strength was significantly reduced in mice that developed early phenotype but not the rest of the mice over-expressing TGF-β1. The asterisks indicate significant differences with <i>p</i><0.05.