Hypnotic and hypothermic effects of high doses of ethanol.

<p>Latency to lose righting reflex (LORR; <i>A</i>) and duration of LORR (<i>B</i>) following a 4.0 g/kg injection of ethanol in wild-type and F639A Het mice (n = 17–18 for each group). Values are mean ±SEM. (<i>C</i>), Change in body temperature following a 3.5 g/kg injection of ethanol in wild-type and F639A Het mice (n = 10 for each group). Values are mean ±SEM. (<i>D</i>), Rate of blood ethanol metabolism between wild-type and F639A Het mice. Blood ethanol concentration (mean ±SEM) measured over time following injection with 4.0 g/kg of ethanol (n = 7 for each group).