Hippocampal-dependent memory deficits are observed in 13–15 month old hAPP mice.

<p>A, Performance in the acquisition portion of the Morris water maze. In the cued platform portion, 2-way repeated measures ANOVA indicates an overall difference between NTG and hAPP mice (p<0.01). Asterisk denotes p<0.05 for individual data points. There was also a significant difference between NTG and hAPP mice in the hidden platform portion of the water maze, although no individual point reached significance in post-hoc tests (2-way repeated measures ANOVA p<0.01). B–C, During the probe trial test for memory that occurred 24 hrs after the last training trial of the hidden platform acquisition phase, NTG mice spent more time in the target quandrant relative to the other three quadrants (B) whereas hAPP mice did not (C). D, The latency for hAPP mice to reach the correct quadrant for the first time during the probe trial was higher than that for NTG mice. E, Representative paths swum during the probe trial for a NTG and an hAPP mouse. F, Swim speed was lower for hAPP mice than NTG mice in the cued portion of the water maze, but was similar to NTG mice during the hidden platform portion of the maze. Swim speeds were compared by assessing the average swim speeds over all sessions in the cued or hidden platform portions of the test. n = 7–11/genotype. T, target; AR, adjacent right; AL, adjacent left; OP, opposite. *p<0.05, **p<0.01.