Double-label confocal immunofluorescence illustrating localization of calbindin (CB) and GPR55.

<p>Flattened Z-series showing CB-immunoreactive cones photoreceptors (green) in the monkey extrafoveal (<b>A–C</b>) and middle (<b>D–F</b>) retina, and these were not GPR55-immunoreactive (magenta). Note that GPR55-IR appears co-localized around the cones, but a 3D reconstruction in the X-Z and Y-Z axes showed no co-localization (<b>G</b>). This micrograph shows that the GPR55-immunoreactivity was adjacent to the CB-immunoreactive cone photoreceptors. ONL, outer nuclear layer; OPL, outer plexiform layer. Scale bar = 30 µm.