DUSP1 is responsible for the host restriction of MVA in MEFs.

<p><b>A</b>) Viral growth of MVA in DUSP1 WT and KO cells infected at 0.01 PFU/cell. Samples of released and cell-associated virus were collected at 0, 24, 48 and 72 hours post-infection and viral titers were determined by immunostaining plaque assay in DF-1 cells. <b>B</b>) Immunostaining plaque assay of MVA infection in DUSP1 WT and KO cells infected as in A. <b>C</b>) Cytopathic effect observed in DUSP1 WT and KO cells infected with MVA as in A. p<0.05 (*), p<0.005 (**) and p<0.001 (***).