Behavior of <i>Csmd1</i> KO and WT mice to acoustic stimuli and tail suspension.

<p>(A) Startle responses of <i>Csmd1</i> KO mice in response to acoustic stimuli in the range of 80–120 dB, as compared to WT mice. The startle baseline was similar in male and female WT mice. A marginal increase in startle responses could be observed for higher acoustic stimuli in both genders of <i>Csmd1</i> KO mice, reaching statistical significance when analyzing all mice together (genotype-group interaction <i>P</i>-value<0.05). (B) There was no difference in amplitude response between KO and WT mice in the degree of inhibition after pre-pulse inhibition. (C) Tail suspension test demonstrated longer accumulated time immobile for KO mice as compared WT mice (P-value<0.05). Borderline statistical significance was observed for male <i>Csmd1</i> KO mice as compared to WT mice (P-value = 0.1).