Expression levels of proinflammatory cytokines in mesothelial cells and peritoneal secretion of TGF-β in response to Freund's adjuvant treatment.

<p>(A) mRNA expression levels of IL-1alpha (IL1a), IL-1beta (IL1b) and IL-6 increase significantly until the third day where expression reaches a maximum, then declines to a similar level measured at the beginning of inflammation induction. (B) TGF-β in the peritoneal cavity follows the same pattern. Western blot using Pan-TGF-β antibody, 46 kDa. M: male F: female. (C) Relative levels of secreted TGF-β measured by densitometry. The asterisks show significant differences from the control group (p<0,05).