Fluxes and control coefficients in the yeast metabolic model.

<p>(A) Fluxes obtained from Geometric FBA. Only selected reactions with large fluxes are depicted, co-substrates are not shown (flux directions and magnitudes shown by arrows). (B) Flux control coefficients. Top: Control exerted by the glucose transporter (GluT). Unscaled flux control coefficients are shown in shades of blue (positive values) and red (negative values). Bottom: control exerted by the biomass production reaction. High-flux reactions respond most strongly: an increased glucose import increases the glycolytic flux, while increased biomass production directs fluxes to other pathways and thereby decreases the glycolytic flux. Flux control coefficients for a model with allosteric regulation are shown in Figures G and H in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079195#pone.0079195.s001" target="_blank">File S1</a>.