R39C <i>unc-18</i> mutants are resistant to aldicarb.

<p>Null <i>unc-18</i> (<i>e81</i>) worms were rescued transgenically with wild-type (Wt) <i>unc-18</i> or <i>unc-18</i> with the indicated mutations. The aldicarb sensitivity of the R39C and R39C/E465K mutants were significantly decreased in comparison to Wt <i>unc-18</i>. Significance was assessed by two-way analysis of variance with post-hoc comparisons. R39C (P<0.001) and R39C/E465K (P<0.001) were different from Wt, but not from each other (P=0.71). N = 3 experiments per strain (20-25 worms each experiment).