Impact of myriocin and antifungal drugs on the <i>Galleria mellonella</i> hemograms.

<p>Hemocyte numbers (cells/ml) of <i>G. mellonella</i> larvae were determined 24 h after injection with <i>C. albicans</i> and/or drugs. The PBS group showed a significant increase in hemocyte numbers (*p<0.001, n = 20) and all the other groups showed a decrease of the hemocytes in comparison with control (CT). In particular, AMPH and MYR+AMPH groups showed decreased numbers (**p<0.001, n = 20). In all the groups where <i>Candida</i> was present, the hemocyte numbers were lower (***p<0.0001, n = 20). Controls were uninjected (CT) or PBS injected larvae. The drug treatments and abbreviations are as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078905#pone-0078905-g001" target="_blank">Figure 1</a>. Error bars indicate standard errors. Each experiment was triplicated.