Tumor therapy studies with IL12-SS1 (Fv).

<p>(A) Treatment of 8-week old female athymic nude mice with IL12-SS1 (Fv) after intraperitoneal injection of LMB-H226-GL. SS1P (0.4 mg/kg), IL12-SS1 (Fv) (0.4 mg/kg), IL12-SS1 (Fv) (1.6 mg/kg), or vehicle (PBS) were intraperitoneally injected times at days 13, 15, 17, and 19 post-injection. Tumor growth was measured by bioluminescence photometry at day 18, 21, and 31. The photometry of the <i>in </i><i>vivo</i> imaging was acquired using Living Image 3.1.0 software (Caliper Life Sciences). *Indicates the significant (<i>p</i> < 0.05) difference between treatment and control (vehicle) by using the one-way ANOVA statistical test (GraphPad Prism 5.03). (B) Photograph of representative mice treated with IL12-SS1 (Fv), SS1P and vehicle (PBS).