Example active compound discovered with the Rtt109 HTS and post-HTS triage.
- Jayme L. Dahlin (486120)
- Rondedrick Sinville (486121)
- Jonathan Solberg (486122)
- Hui Zhou (13228)
- Junhong Han (147191)
- Subhashree Francis (486123)
- Jessica M. Strasser (486124)
- Kristen John (381275)
- Derek J. Hook (486125)
- Michael A. Walters (486126)
- Zhiguo Zhang (147197)
Publication date
November 2013
DOIAbstract
<p>(A) CPM-based assay dose-response with compound <b>1</b>. Fluconazole = negative control compound. (B) Orthogonal slot blot assay to detect the presence of H3K56ac by Western blot. Equal protein content was verified for each membrane by Ponceau S staining. (C) Dose-response of compound <b>1</b> using a [<sup>3</sup>H]-acetyl-CoA orthogonal assay.</p
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