a<p>significantly different from their respective WT control value (<i>p</i><0.05, unpaired t-test versus WT cTn).</p>b<p>Significantly different from their respective SD values (<i>p</i><0.05, unpaired t-test versus SD cTn).</p>c<p>ΔK<sub>F1/2</sub> = K<sub>F1/2</sub> of various cTn−K<sub>F1/2</sub> of WT cTn.</p
In failing human myocardium changes occur, in particular, in isoform composition and phosphorylation...
Cardiac diseases associated with mutations in Tn subunits include hypertrophic cardiomyopathy (HCM),...
<p>Data are given as mean ± SEM.</p><p><sup><i>a</i></sup>Significantly different from their respect...
<p>The changes of force-pCa relationship as sarcomere length (SL) was increased from 1.9 to 2.3 µm i...
<p>(A) The comparison of the force-pCa relationships of skinned cardiac myocytes containing either W...
Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mu...
Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mu...
Three novel mutations (G159D, L29Q and E59D/D75Y) in cardiac troponin C (CTnC) associate their clini...
<p>(<b>A</b>) Representative Western blot showing non-transduced (WT), R146G cTnI, and A63V Tm + R14...
<p><b>A</b>. Shortening-[Ca<sup>2+</sup>] phase loop plots show that OVX caused a rightward shift in...
How different mutations in cardiac troponin T (cTnT) lead to distinct secondary downstream cellular ...
<p>The contractile parameters of spontaneously contracting cardiomyocytes measured after 2 h incubat...
<p>(<i>A</i>) Representative cardiomyocyte Ca<sup>2+</sup> transients and (<i>B</i>) corresponding b...
<p>(A) Representative signal averaged sarcomere length measurements during contraction recorded from...
To determine optimal live-cell parameters for Indo-1 and TN-L15 in myocytes, we utilized a sequentia...
In failing human myocardium changes occur, in particular, in isoform composition and phosphorylation...
Cardiac diseases associated with mutations in Tn subunits include hypertrophic cardiomyopathy (HCM),...
<p>Data are given as mean ± SEM.</p><p><sup><i>a</i></sup>Significantly different from their respect...
<p>The changes of force-pCa relationship as sarcomere length (SL) was increased from 1.9 to 2.3 µm i...
<p>(A) The comparison of the force-pCa relationships of skinned cardiac myocytes containing either W...
Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mu...
Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mu...
Three novel mutations (G159D, L29Q and E59D/D75Y) in cardiac troponin C (CTnC) associate their clini...
<p>(<b>A</b>) Representative Western blot showing non-transduced (WT), R146G cTnI, and A63V Tm + R14...
<p><b>A</b>. Shortening-[Ca<sup>2+</sup>] phase loop plots show that OVX caused a rightward shift in...
How different mutations in cardiac troponin T (cTnT) lead to distinct secondary downstream cellular ...
<p>The contractile parameters of spontaneously contracting cardiomyocytes measured after 2 h incubat...
<p>(<i>A</i>) Representative cardiomyocyte Ca<sup>2+</sup> transients and (<i>B</i>) corresponding b...
<p>(A) Representative signal averaged sarcomere length measurements during contraction recorded from...
To determine optimal live-cell parameters for Indo-1 and TN-L15 in myocytes, we utilized a sequentia...
In failing human myocardium changes occur, in particular, in isoform composition and phosphorylation...
Cardiac diseases associated with mutations in Tn subunits include hypertrophic cardiomyopathy (HCM),...
<p>Data are given as mean ± SEM.</p><p><sup><i>a</i></sup>Significantly different from their respect...