<p>(A) Percentage change in body weight after challenge in mice. Changes in body weight (n=10) are expressed as the mean in each group. (B) Survival rate after challenge in mice. Symbols: AcHERV-sH1N1-HA–vaccinated C57BL/6, filled red diamonds; AcHERV-sH1N1-HA–vaccinated BALB/C, open red diamonds; killed virus-vaccinated C57BL/6, filled green triangles; killed virus-vaccinated BALB/C, open green triangles; PBS-injected C57BL/6, filled grey circles; PBS-injected BALB/C, open grey circles. *P<0.05 compared with PBS-injected mice; repeated measures ANOVA from day 1 to day 14 post infection.</p
<p>(A–B) At six months after prime-boost immunizations with M2 VLPs, mice (n = 5) were challenged wi...
<p><b>Mice (n = 6/groups) were immunized intranasally on day 0 and 28.</b> All groups were challenge...
<p>Survival rates (A, C) and average body weight loss (B, D) of BALB/c (A, B) or C57BL/6 (C, D) mice...
<p>Mice (n = 10/groups) were immunized subcutaneously on day 0 and 28. All groups were challenged in...
<p>A–B: Protection against A/California/04/2009 virus challenge. Mice intramuscularly immunized with...
<p>(<b>a</b>) Schematic diagram of the immunization and challenge studies. (<b>b</b>) At 2 weeks aft...
<p>At 18 days following the last immunization, all mice in study group B were intranasally challenge...
<p>(A–B) Groups of vaccinated mice and a mock control were intranasally challenged with a lethal dos...
<p>Kaplan-Meier survival curves (left), mean bodyweight change (middle) and median clinical score (r...
<p>At week 5, mice vaccinated with clade 2-dervied vaccines were challenged intranasally with a leth...
<p>Mice (n = 6/groups) were immunized subcutaneously on day 0 and 28. All groups were challenged int...
<p>At day 42, vaccinated mice were challenged intranasally with a lethal dose (100 LD<sub>50</sub>) ...
<p>(A–C) Groups of 9 BALB/c mice were vaccinated with 10<sup>10</sup> vp/mouse of PAV3-HA (▵), AdHu5...
<p>At week 30 post immunization, H5N1 VLP immunized and control (PBS or 5 µg inactivated PR/8/34 H1N...
<p>Mice were challenged one month after vaccination (0.5 µg PZQ/0.1 µg antigen). (A) Viral loads in ...
<p>(A–B) At six months after prime-boost immunizations with M2 VLPs, mice (n = 5) were challenged wi...
<p><b>Mice (n = 6/groups) were immunized intranasally on day 0 and 28.</b> All groups were challenge...
<p>Survival rates (A, C) and average body weight loss (B, D) of BALB/c (A, B) or C57BL/6 (C, D) mice...
<p>Mice (n = 10/groups) were immunized subcutaneously on day 0 and 28. All groups were challenged in...
<p>A–B: Protection against A/California/04/2009 virus challenge. Mice intramuscularly immunized with...
<p>(<b>a</b>) Schematic diagram of the immunization and challenge studies. (<b>b</b>) At 2 weeks aft...
<p>At 18 days following the last immunization, all mice in study group B were intranasally challenge...
<p>(A–B) Groups of vaccinated mice and a mock control were intranasally challenged with a lethal dos...
<p>Kaplan-Meier survival curves (left), mean bodyweight change (middle) and median clinical score (r...
<p>At week 5, mice vaccinated with clade 2-dervied vaccines were challenged intranasally with a leth...
<p>Mice (n = 6/groups) were immunized subcutaneously on day 0 and 28. All groups were challenged int...
<p>At day 42, vaccinated mice were challenged intranasally with a lethal dose (100 LD<sub>50</sub>) ...
<p>(A–C) Groups of 9 BALB/c mice were vaccinated with 10<sup>10</sup> vp/mouse of PAV3-HA (▵), AdHu5...
<p>At week 30 post immunization, H5N1 VLP immunized and control (PBS or 5 µg inactivated PR/8/34 H1N...
<p>Mice were challenged one month after vaccination (0.5 µg PZQ/0.1 µg antigen). (A) Viral loads in ...
<p>(A–B) At six months after prime-boost immunizations with M2 VLPs, mice (n = 5) were challenged wi...
<p><b>Mice (n = 6/groups) were immunized intranasally on day 0 and 28.</b> All groups were challenge...
<p>Survival rates (A, C) and average body weight loss (B, D) of BALB/c (A, B) or C57BL/6 (C, D) mice...