Molecular modeling of the POU4F3 protein constructed by the 2xsd protein as the template.

<p>(A) Overview of the modeled POU4F3 domain. The protein chain is shown in grey using a ribbon representation, the position of the mutated residue is indicated in green, the DNA is shown as a ball-and-stick model and colored yellow. (B) A close-up view of the mutated residue. The side chains of the wild-type and the mutant residue are shown in green and red, respectively. The figures show that the wild-type Arginine residue interacts with the phosphate backbone of the DNA, while the mutant Lysine residue is slightly shorter than Arginine and cannot make the same interactions with DNA.