Post-vaccination EV71 neutralizing antibody response against EV71 strains of subgenotype B4, B5, C2, C4 and C5, stratified by pre-vaccination titer.

<p>N: number of total participants included in the analyses. Data are GMT (95% CI) or GMFI (95% CI). GMT, geometric mean titer; GMFI, fold increase in geometric mean titers. Seroconversion is defined as pre-vaccination titre less than 1∶8 and post-vaccination titre 1∶32 or more, or pre-vaccination titre 1∶8 or more and at least four-fold increase post-vaccination.</p>a<p>Negative antibody titers (i.e., <1∶8) were assigned a value of 1∶4 for calculation purposes.</p>#<p>Seroconversion rate was significantly higher in the initially seronegative infants and children than the initially seropositive infants and children after vaccination (p<0.05 in both cases).</p>*<p>The GMTs of neutralizing antibodies against five EV71 subgenotypes increase significantly after vaccination (p<0.0001 in both cases).</p>&<p>Seroconversion rate were not significantly different among the five EV71 subgenotypes after vaccination. (initially seronegative group: χ² = 3.00, p>0.05; initially seropositive group: χ² = 2.19, p>0.05).