Increase of the formation of newborn projection neurons in adult ischemic brain by exercise post-stroke.

<p>Double immunohistochemical staining of FG (blue) and GFP (brown) was used to detect newly generated projection neurons. A: Histochemical photographs showed GFP⁺-FG⁺ double staining cells as indicated by double red arrowheads. GFP⁺ and FG⁺ single-labeling cells were indicated by single red arrow and arrowhead, respectively. B: Quantitative analysis showed that exercise post-stroke significantly increased the number of newborn striato- and cortico-nigral projection neurons in ischemic rat brain. Data are shown as mean ± S.E.M. MCAO group (n = 8); MCAO+Ex group (n = 6). *<i>P</i><0.05 <i>vs</i> MCAO group. Scale bar in A is 100 µm.