<div><p>The NMDAR glutamate receptor subtype mediates various vital physiological neuronal functions. However, its excessive activation contributes to neuronal damage in a large variety of acute and chronic neurological disorders. NMDAR antagonists thus represent promising therapeutic tools that can counteract NMDARs’ overactivation. Channel blockers are of special interest since they are use-dependent, thus being more potent at continuously activated NMDARs, as may be the case in pathological conditions. Nevertheless, it has been established that NMDAR antagonists, such as MK801, also have unacceptable neurotoxic effects. Presently only Memantine is considered a safe NMDAR antagonist and is used clinically. It has recently been speculated ...
NMDA receptors are ionotropic glutamate receptors (iGluR) activated by the amino acid glutamate and ...
The activation of N-methyl-D-aspartate glutamate receptors (NMDARs) is required for the long term po...
The impairment of glutamatergic neurotransmission plays an important role in the development of Alzh...
The NMDAR glutamate receptor subtype mediates various vital physiological neuronal functions. Howeve...
The NMDAR glutamate receptor subtype mediates various vital physiological neuronal functions. Howeve...
International audienceOver-stimulation of NMDA receptors (NMDARs) is involved in many neurodegenerat...
International audienceUNLABELLED: ABSTRACT: BACKGROUND: Tissue plasminogen activator (tPA) exerts mu...
Excitotoxicity is thought to be a major mechanism in many human disease states such as ischemia, tra...
<div><p>(<b>A</b>) Analysis of locomotive behaviour 10 min after the drug administration showed that...
NMDA (N-methyl-D-aspartate) receptors are glutamate-gated ion channels, which are located in the cen...
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes problems with ...
Mutations in N-methyl-d-aspartate receptors (NMDAR) subunits have been implicated in a growing numbe...
<div><p>(<b>A</b>) Comparison of the intrinsic neurotoxicity of GK11 or MK801 on densely seeded and ...
Inappropriate activation of NMDA receptors during a period of cerebral ischaemia is a crucial event ...
In the 1950s, Sernyl, more commonly known as phencyclidine (PCP), was created, and marketed as a sur...
NMDA receptors are ionotropic glutamate receptors (iGluR) activated by the amino acid glutamate and ...
The activation of N-methyl-D-aspartate glutamate receptors (NMDARs) is required for the long term po...
The impairment of glutamatergic neurotransmission plays an important role in the development of Alzh...
The NMDAR glutamate receptor subtype mediates various vital physiological neuronal functions. Howeve...
The NMDAR glutamate receptor subtype mediates various vital physiological neuronal functions. Howeve...
International audienceOver-stimulation of NMDA receptors (NMDARs) is involved in many neurodegenerat...
International audienceUNLABELLED: ABSTRACT: BACKGROUND: Tissue plasminogen activator (tPA) exerts mu...
Excitotoxicity is thought to be a major mechanism in many human disease states such as ischemia, tra...
<div><p>(<b>A</b>) Analysis of locomotive behaviour 10 min after the drug administration showed that...
NMDA (N-methyl-D-aspartate) receptors are glutamate-gated ion channels, which are located in the cen...
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes problems with ...
Mutations in N-methyl-d-aspartate receptors (NMDAR) subunits have been implicated in a growing numbe...
<div><p>(<b>A</b>) Comparison of the intrinsic neurotoxicity of GK11 or MK801 on densely seeded and ...
Inappropriate activation of NMDA receptors during a period of cerebral ischaemia is a crucial event ...
In the 1950s, Sernyl, more commonly known as phencyclidine (PCP), was created, and marketed as a sur...
NMDA receptors are ionotropic glutamate receptors (iGluR) activated by the amino acid glutamate and ...
The activation of N-methyl-D-aspartate glutamate receptors (NMDARs) is required for the long term po...
The impairment of glutamatergic neurotransmission plays an important role in the development of Alzh...