Effect of salinomycin and paclitaxel on primary tumor growth and lung metastasis development.

<p><b>A.</b> Primary tumor volumes. Paclitaxel delays tumor growth compared with control mice. The arrow indicates the day of treatment initiation. <b>B.</b> Macroscopic evaluation of the number of lung macrometastasis. Mice administered with salinomycin display a reduction in the number of lung macrometastatic foci compared with control mice. Animals that received paclitaxel show a higher number of macrometastasis compared with salinomycin treated mice. <b>C.</b> Representative histological images of lungs from control mice and salinomycin or paclitaxel injected mice. Quantification of metastasis by image analysis in histological sections. Data are expressed as percentage of area occupied by metastatic nodules with respect to area of the normal lung. Data and error bars show mean ± SEM. 5 animals per group were used. S: Salinomycin. P: Paclitaxel *p<0.05.