DUX4-bound regions are similarly activated in FSHD patient myotubes and in <i>DUX4</i>-transduced myoblasts.

<p>(A) DUX4-bound regions show correlated activation levels in FSHD patient myotubes and in our <i>DUX4</i>-transduced myoblast experimental system. We show log2-activation levels in each system, counting RNA-seq reads within an arbitrary 1 kb of DUX4-bound regions as for <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003947#pgen-1003947-g003" target="_blank">Figure 3A</a>. “+” symbols show bound repetitive elements and dot symbols are unique regions. Green symbols show regions that reach statistical significance in only the <i>DUX4</i>-transduced myoblasts, blue symbols are significant in only the FSHD myotubes, and red symbols are significant in both comparisons. The dotted line is a regression line (slope 0.265). (B) Internal regions of ERV and MaLR repeats show correlated activation levels in FSHD patient myotubes and in our <i>DUX4</i>-transduced myoblast experimental system. Colors as in panel A. The dotted line is a regression line (slope 0.270).