Repertoire of functional enrichments in human proteome.

<p>Repertoire of enrichment dependencies of GO (gene ontology) terms on the order measures of regularity, RC (black), and periodicity, RP (red). Portions of proteins belonging to a functional group are estimated based on text search in GO terms (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003346#s4" target="_blank">methods</a>) and plotted in double axes against increasing thresholds of RC (lower x-axis) and RP (upper x-axis). A) The portions of some terms that are enriched with increasing threshold of RC but not of RP, like keratin (solid) and collagen (dotted). In this category one finds also filament and cell adhesion related proteins. B) GO terms that are enriched only for increased RP threshold but not RC, as neuronal related proteins (solid) and immune system proteins (dotted). These include also synaptic function and cell response genes. C) Other terms like extracellular region are enriched with increasing the threshold of both RC and RP. D) Some functionalities show more complicated non-monotonic “bump” behaviors. These include DNA-binding, regulation and transcription. As an example, DNA binding are further analyzed showing functional dependencies on RP and RC of both repetitive sections (MFI>1) and runs (MFI = 1). E) MFI = 1 proteins exhibit stable enrichment pattern as function of the threshold on the sum of repetitions at MFI = 1 (i.e., the effective coverage of all amino-acids “runs”). F) Disease related proteins are enriched with increasing length of runs. In each plot, the portion of the corresponding GO-term in the entire CO Swiss-Prot reviewed proteome is the value displayed at 0.