Malarial challenge of wild type and Ifitm3^-/- mice with <i>P. berghei</i> ANKA.

<p>Mice were intraperitoneally injected with red blood cells containing <i>P. berghei</i> ANKA and were monitored for survival for 12 days pi. n = 9 for wild type, n = 2 for each of Ifitm3^-/- and Ifngr^-/- mutants (<b>A</b>). Parasite biomass was monitored by measuring the activity of a luciferase reporter gene constitutively expressed by the parasite and expressed as relative light units (RLU) (<b>B</b>), and cytokine dysregulation was measured from the sera on day three pi by cytometric bead assay (<b>C</b>). ■: wild type, □: Ifitm3^-/-, ○: Ifngr^-/-. Results show means ± S.D. (n > 2).