Neutralization assays on JR-FL glycan mutants indicate binding of inferred intermediate antibodies to both N301 and N332 on HIV-1 Env.
- Devin Sok (409518)
- Uri Laserson (11926)
- Jonathan Laserson (488297)
- Yi Liu (36759)
- Francois Vigneault (5656918)
- Jean-Philippe Julien (135641)
- Bryan Briney (488298)
- Alejandra Ramos (386538)
- Karen F. Saye (488299)
- Khoa Le (488300)
- Alison Mahan (488301)
- Shenshen Wang (488302)
- Mehran Kardar (21488)
- Gur Yaari (188074)
- Laura M. Walker (244449)
- Birgitte B. Simen (372038)
- Elizabeth P. St. John (488303)
- Po-Ying Chan-Hui (488304)
- Kristine Swiderek (488305)
- Stephen H. Kleinstein (488306)
- Galit Alter (91383)
- Michael S. Seaman (155998)
- Arup K. Chakraborty (97)
- Daphne Koller (47384)
- Ian A. Wilson (113692)
- George M. Church (102039)
- Dennis R. Burton (106420)
- Pascal Poignard (244468)
Publication date
November 2013
DOIAbstract
<p>(<b>A</b>) Neutralization curves of inferred intermediate antibodies on wild-type JR-FL virus (<b>B</b>) JR-FL N301A mutant virus, and (<b>C</b>) JR-FL N332A mutant virus. (<b>D</b>) Neutralization curves of 3H+3L and (<b>E</b>) PGT121 on wild-type JR-FL virus compared to single and double glycan mutant viruses. (<b>F</b>) Neutralization curves of PGT121 on wild-type 92BR020 virus compared to single and double glycan mutant viruses.</p
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