TLQP-21 increases the NADPH level without promoting cell growth.

<p>(A) The absorbance value of MTS assay with different treatments; the mannitol group was set as hyperosmosis control. *p<.05, **p<.01 vs. NC group; ^# p<.05, ^##p<.01 vs. HG group. (B) Cell proliferation curve of HUVECs with different treatments. ^#p<.05, ^##p<.01 NC&TLQP-21 group vs. HG group; *p<.05, **p<.01 HG+TLQP-21 group vs. HG group. (C) NADPH level of HUVECs with different treatments. **p<.01 vs. NC group; ^##p<.01 vs. TLQP-21(10 nM) group. (D) Comparison of the NADPH level of HUVECs with and without TLQP-21(50 nM) treatment; the mannitol group was set as a hyperosmosis control. *p<.05, *p<.01 vs. TLQP-21 withdraw group. All data were collected from three independent experiments and are presented as the mean ±SD.