Cytokine Production.

<p>Cytokine produced (A, C, E, G) proliferative and (B, D, F, H) quiescent SMCs in response to DS-SILY₂₀. The amount of (A, B) IFN-γ, (C, D) IL-1β, (E, F) IL-6, and (G, H) TNF-α produced by cultured SMCs was measured 24 hrs post-treatment. For proliferative SMC cultures, a general trend was observed such that as the concentration of DS-SILY₂₀ increased, cytokine production decreased. Significant reductions in IFN-γand TNF-α were also observed in quiescent SMC cultures with the addition of DS-SILY₂₀. * represents significance from control non-treated cells. (Nγ6).