Beclin 1 expression in subtypes of ICC and ECC.

<p>Immunohistochemistry analysis of Beclin 1 expression in ICC (A) and ECC (B). Beclin 1 was lowly or moderately expressed in cancer cell cytoplasma, whereas highly expressed in the well differentiated tissue (original magnification, x100). The lower panel displayed the enlarged view (original magnification, x400). (C) The subset patient distribution according to the Beclin 1 expression level in ICC and ECC. (D) Beclin 1 was downregulated in the patients with lymph node metastasis, whereas was upregulated in the subset without lymph node metastasis (original magnification, x100). The lower panel displayed the enlarged view (original magnification, x400).