<p>(A) Initially, the protein expression levels and the expression difference (<i>ED</i>) between cancer tissue and normal tissue for all antibodies covering all mappings are calculated. (B) The significance of the target <i>ED</i> with respect to the mapping of interest is determined by a cumulative z distribution. (C) The specificity of the target <i>ED</i> with respect to the mapping of interest is determined by another cumulative z distribution. (D) The final score of the antibody with respect to the mapping of interest is determined on the basis of its protein expression level in cancer tissue and the significance and specificity of its <i>ED</i>.</p
*<p>randomly selected single tumor samples per case; this analysis was repeated 3 times (tumor sampl...
Cancer marker discovery is an emerging topic in high-throughput quantitative proteomics. However, th...
<p>The amount of antigen in a given location was characterized as 0 (none), 1+ (minimal), 2+ (mild),...
Current methods used to evaluate in vivo target efficacy of selected compound include western blot t...
<p>Current methods used to evaluate in vivo target efficacy of selected compound include western blo...
<p>Relative concentrations of plasma antibody species was determined by ELISAs. (A) Antibody profile...
<p>The z-scores for signal intensity of antibody binding by age-stratified sera from the hilltop and...
<p>Concentrations are calculated as described in equation (1). The percentage of protein that is Aff...
Quantification of protein expression based on immunohistochemistry (IHC) is an important step for tr...
a-b) Enrichment of the proliferation signature in proteins associated with cancer stage (a) and grad...
<p>Scoring criteria of Immunohistochemistry (IHC) assay with specific antibodies used in this study....
In situ protein detection in human tissues using antibodies reveals the cellular protein localizatio...
<p>Protein levels in tumor tissues detected in RPPA assay were analyzed for associations with clinic...
<p>The staining intensity of representative images of the tumor versus the surrounding mucosa tissue...
International audienceThe outcome prediction in cancer is usually achieved by evaluating tissue samp...
*<p>randomly selected single tumor samples per case; this analysis was repeated 3 times (tumor sampl...
Cancer marker discovery is an emerging topic in high-throughput quantitative proteomics. However, th...
<p>The amount of antigen in a given location was characterized as 0 (none), 1+ (minimal), 2+ (mild),...
Current methods used to evaluate in vivo target efficacy of selected compound include western blot t...
<p>Current methods used to evaluate in vivo target efficacy of selected compound include western blo...
<p>Relative concentrations of plasma antibody species was determined by ELISAs. (A) Antibody profile...
<p>The z-scores for signal intensity of antibody binding by age-stratified sera from the hilltop and...
<p>Concentrations are calculated as described in equation (1). The percentage of protein that is Aff...
Quantification of protein expression based on immunohistochemistry (IHC) is an important step for tr...
a-b) Enrichment of the proliferation signature in proteins associated with cancer stage (a) and grad...
<p>Scoring criteria of Immunohistochemistry (IHC) assay with specific antibodies used in this study....
In situ protein detection in human tissues using antibodies reveals the cellular protein localizatio...
<p>Protein levels in tumor tissues detected in RPPA assay were analyzed for associations with clinic...
<p>The staining intensity of representative images of the tumor versus the surrounding mucosa tissue...
International audienceThe outcome prediction in cancer is usually achieved by evaluating tissue samp...
*<p>randomly selected single tumor samples per case; this analysis was repeated 3 times (tumor sampl...
Cancer marker discovery is an emerging topic in high-throughput quantitative proteomics. However, th...
<p>The amount of antigen in a given location was characterized as 0 (none), 1+ (minimal), 2+ (mild),...