Bone morphogenetic protein (BMP) signaling pathways are essential regulators of chondrogenesis. However, the roles of these pathways in vivo are not well understood. Limb-culture studies have provided a number of essential insights, including the demonstration that BMP pathways are required for chondrocyte proliferation and differentiation. However, limb-culture studies have yielded contradictory results; some studies indicate that BMPs exert stimulatory effects on differentiation, whereas others support inhibitory effects. Therefore, we characterized the skeletal phenotypes of mice lacking Bmpr1a in chondrocytes (Bmpr1aCKO) and Bmpr1aCKO;Bmpr1b+/- (Bmpr1aCKO;1b+/-) in order to test the roles of BMP pathways in the growth plate in vivo. The...
Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome achondrop...
Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome achondrop...
AbstractMutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome a...
Bone morphogenetic protein (BMP) signaling pathways are essential regulators of chondrogenesis. Howe...
TGFβ and BMP signaling pathways exhibit antagonistic activities during the development of many tissu...
Previous studies have demonstrated the ability of bone morphogenetic proteins (BMPs) to promote chon...
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Throu...
AbstractFibroblast growth factors (FGFs) and their receptors (FGFRs) play significant roles in verte...
Although bone morphogenetic proteins (BMPs) were initially identified for their potent bone-inducing...
Although bone morphogenetic proteins (BMPs) were initially identified for their potent bone-inducing...
In vivo, long bones are formed by the developmental process of endochondral ossification. This devel...
The bone morphogenetic protein 5 (BMP5) participates in skeletal development but its direct effects ...
Chondrogenic differentiating mesenchymal stem cells (MSCs) are mimicking embryonal endochondral ossi...
The bone morphogenetic proteins (BMPs), TGF superfamily members, play diverse roles in embryogenesi...
Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome achondrop...
Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome achondrop...
Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome achondrop...
AbstractMutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome a...
Bone morphogenetic protein (BMP) signaling pathways are essential regulators of chondrogenesis. Howe...
TGFβ and BMP signaling pathways exhibit antagonistic activities during the development of many tissu...
Previous studies have demonstrated the ability of bone morphogenetic proteins (BMPs) to promote chon...
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Throu...
AbstractFibroblast growth factors (FGFs) and their receptors (FGFRs) play significant roles in verte...
Although bone morphogenetic proteins (BMPs) were initially identified for their potent bone-inducing...
Although bone morphogenetic proteins (BMPs) were initially identified for their potent bone-inducing...
In vivo, long bones are formed by the developmental process of endochondral ossification. This devel...
The bone morphogenetic protein 5 (BMP5) participates in skeletal development but its direct effects ...
Chondrogenic differentiating mesenchymal stem cells (MSCs) are mimicking embryonal endochondral ossi...
The bone morphogenetic proteins (BMPs), TGF superfamily members, play diverse roles in embryogenesi...
Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome achondrop...
Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome achondrop...
Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome achondrop...
AbstractMutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome a...