Changes in degradation and synthesis rates induced by Hsp90 inhibition and relationship with changes in net total protein levels and protein families.

<p>Indexes of variables are A (as in k_A, V_A) for control (+DMSO) and B (as in k_B, V_B) for treated (+GA) cells. A) Scatter plot of the values of ratios of intrinsic degradation constants k_B,d/k_A,d vs. the ratios of synthesis rates V_B/V_A. The median values of k_B,d/k_A,d and V_B/V_A for the population are indicated with dashed lines. Coloring of points is according to the calculated treated /control total protein ratio at t = 20h (ratio <i>S</i>). B) Same as A) but with coloring of ribosomal, proteasome and heat shock proteins. Groups I and II are discussed in the main text. All values are log₂.