The NEDD4 family of E3 ubiquitin ligases.

<p>The nine members of the NEDD4 family are modular proteins. At their N-terminus, each has a C2 domain, which plays a role in proper cellular localization. The central portion of each protein contains two-to-four WW domains, which are responsible for target recognition. WW domains are 20–23 amino acid, Trp-based motifs that recognize PY motifs (PPXY, LPXY), as well as some phospho-Ser- or phospho-Thr-based motifs. At the C-terminus is the HECT domain, which directly conjugates an ubiquityl moiety to the target protein. The family members are grouped together by name and homology. ITCH is more closely homologous to WWP1 and 2 than to other family members.