Regional neuroinflammation in AD subjects and controls measured with [³H]PK11195 autoradiography.

<div><p>A. Representative autoradiographic and anatomical images. </p> <p>Top –Hippocampal anatomy is shown on the left followed by a representative pseudocolored TSPO autoradiogram from hippocampus of a control subject and a representative autoradiogram from hippocampus of a subject with AD. The bottom row depicts striatal anatomy on the left followed by a representative TSPO autoradiogram from a control striatum and a representative autoradiogram from a subject with AD. </p> <p>Autoradiograms were pseudocolored using the rainbow spectrum (bar on the right).</p> <p>B. Quantitative autoradiographic measurements of regional TSPO density (expressed as specific binding of [3H]PK11195 in nCi/mg tissue).</p> <p>Abbreviations: CA1-4 cornu ammoni fields of the hippocampus, DG=gentate gyrus, SubP=subpyramidal layers of CA1, Sub=subiculum, ECx=entorhinal cortex, Str=striatum. </p> <p>*p<0.05, **p<0.005 AD relative to control; ANOVA followed by Fisher’s PLSD posthoc test. </p> <p>C. TSPO density in CA1 pyramidal cell body layer as a function of Braak stage (left) and genotype (right). </p> <p>*p<0.05 relative to Braak stages 0-II, one way ANOVA followed by Fisher’s PLSD posthoc test.</p> <p>**p<0.005, student’s t test. </p>