<i>In-vivo</i> PKCζ inhibition in 6-month-old-diabetic rats partially restores PKCζ staining pattern in cone outer segments.
- Samy Omri (355064)
- Francine Behar-Cohen (64434)
- Pierre-Raphaël Rothschild (491025)
- Emmanuelle Gélizé (154579)
- Laurent Jonet (64432)
- Jean Claude Jeanny (491026)
- Boubaker Omri (491027)
- Patricia Crisanti (491028)
Publication date
November 2013
DOIAbstract
<p>The phosphorylated active form PKCζ-P (green) was found in IS of both control (CTL) and diabetic (DIA) rats (a). Diabetic inhibitor (DIA+IZ) treated rats showed partial restoration of OS PKCζ (red) staining (a). We performed laser micro dissection of the photoreceptor layer on cryosections (b) to study layer-specific protein level by Western blotting analysis. The PKCζ-P immunoreactivity increase found in diabetic rats (DIA) was partially restored in treated rats (DIA+IZ).</p
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