<div><p>The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and therefore represents a promising therapeutic target. It exerts its biological task by inhibiting the Wnt (wingless and int1) signaling pathway, which participates in bone formation by promoting the differentiation of mesenchymal stem cells to osteoblasts. The core structure of Sclerostin consists of three loops with the first and third loop (Finger 1 and Finger 2) forming a structured β-sheet and the second loop being unstructured and highly flexible. Biochemical data showed that the flexible loop is important for binding of Sclerostin to Wnt co-receptors of the low-density lipoprotein related-protein family (LRP), by interacting wit...
Background: Sclerosteosis, a severe autosomal recessive sclerosing skeletal dysplasia characterised ...
Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is ...
AbstractMechanical loading is the primary functional determinant of bone mass and architecture, and ...
The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and...
The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and...
<div><p>Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in t...
Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in the SOST ...
The glycoprotein sclerostin has been identified as a negative regulator of bone growth. It exerts it...
Low-density lipoprotein receptor-related protein 6 (LRP6) is a coreceptor of the beta -catenin-depen...
Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interac...
Sclerostin is an osteocyte-derived negative regulator of bone formation. It inhibits BMP-stimulated ...
Mutations in the LRP4 gene, coding for a Wnt signaling coreceptor, have been found to cause several ...
Context: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteocl...
Sclerosteosis is a severe autosomal recessive sclerosing skeletal dysplasia with no available treatm...
Abstract: Sclerosteosis is a high bone mass disorder, caused by pathogenic variants in the genes enc...
Background: Sclerosteosis, a severe autosomal recessive sclerosing skeletal dysplasia characterised ...
Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is ...
AbstractMechanical loading is the primary functional determinant of bone mass and architecture, and ...
The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and...
The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and...
<div><p>Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in t...
Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in the SOST ...
The glycoprotein sclerostin has been identified as a negative regulator of bone growth. It exerts it...
Low-density lipoprotein receptor-related protein 6 (LRP6) is a coreceptor of the beta -catenin-depen...
Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interac...
Sclerostin is an osteocyte-derived negative regulator of bone formation. It inhibits BMP-stimulated ...
Mutations in the LRP4 gene, coding for a Wnt signaling coreceptor, have been found to cause several ...
Context: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteocl...
Sclerosteosis is a severe autosomal recessive sclerosing skeletal dysplasia with no available treatm...
Abstract: Sclerosteosis is a high bone mass disorder, caused by pathogenic variants in the genes enc...
Background: Sclerosteosis, a severe autosomal recessive sclerosing skeletal dysplasia characterised ...
Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is ...
AbstractMechanical loading is the primary functional determinant of bone mass and architecture, and ...