Plasma glucose (A, B) and insulin (C, D) versus time profiles during 7-day infusions (B and D) of saline (○), 0.03 (▾) and 0.1 (∇) mg/kg/h of MPL, and IV injections (A and C) of saline (Δ), 10 (▪) and 50 (□) mg/kg of MPL.

<p>Lines depict simultaneous fittings of glucose, insulin, and FFA with Eq. (18) – (21) for saline infusion (light dotted line), 0.03 mg/kg/h (heavy dotted line), 0.1 mg/kg/h (light long dash line), saline injection (light dash-dotted line), 10 mg IV (light solid line), and 50 mg IV (heavy solid line). The PD parameters are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0081679#pone-0081679-t006" target="_blank">Table 6</a>.