IL-1β treatments reduce intestinal colonization and dissemination of <i>C. rodentium</i> in <i>Nlrp3^−/−</i> mice.

<p>Infected mice were given repeated IL-1β treatments on 0, 2, and 4 DPI. <i>C. rodentium</i> colonization of the (A) cecum, (B) colon, and (C) dissemination to MLN were assessed on 6 and 10 DPI by plating homogenates on MacConkey agar plates in serial dilutions. IL-1β treatments of <i>Nlrp3^−/−</i> mice significantly lowered cecum colonization on 6 DPI, and colon colonization and dissemination to MLN on 10 DPI. Values were Log₁₀ transformed and data presented as mean ± SE. One asterisk: <i>P</i><0.05, two asterisks: <i>P</i><0.01.