Serum nicotine-specific antibody (NicAb) titers and concentrations of rats immunized with monovalent or bivalent vaccines i.p. in Freund’s adjuvant (mean ± SD).

<p>Immunogen doses are the total administered, i.e. 100 µg bivalent = 50 µg 3′-AmNic-rEPA and 50 µg 6-CMUNic-KL H. NicAb titers (A) in the bivalent group were higher than those in the monovalent 6-CMUNic-KLH group, and NicAb concentrations (B) in the bivalent vaccine were higher than the monovalent 3′-AmNic-rEPA group.