Effect of rapamycin on myocardial mTOR signaling in HF.

<p>Representative Western blots and grouped data for total or Thr389 phosphorylated S6K1 (A) and total or Ser235/236 phosphorylated S6 (B) in SHAM operated (n = 6), placebo treated HF (n = 6) and 8 mg/kg/day PO rapamycin treated HF mice (n = 6). Std: A standard LV homogenate sample for reliable comparison across gels. Data are mean ± SEM. †: <i>P</i><0.05 vs SHAM, ‡: <i>P</i><0.05 vs. placebo treated HF mice.