Molecular components of the catalytic network of the CYP3A4-adrenodoxin (Adx) complex.

<p>Adx is a small iron-sulfur protein that transfers electrons from NADPH to terminal CYP as part of the overall metabolic processing of substrates. We used the structural complex of this enzyme with eukaryotic CYP (CYP11A1) to model a CYP3A4-Adx complex. Selected molecular components of the modeled electron transfer pathway from the CYP3A4 heme iron to the Adx are shown, where the CYP3A4 unit is shown in gray, the Adx unit is shown in yellow, and the residues in the CYP3A4 catalytic networks are shown in green. The heme group is shown in pink, and the CYP3A4 C411 residue is shown in red. All residues involved in the predicted electron-transfer pathway are shown as sticks.